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Symbol
Name
ID

Pld4
phospholipase D family member 4
MGI:2144765

Phenotype annotations related to immune system

*	Aspects of the system are reported to show a normal phenotype.
	Darker colors indicate more annotations

Mouse Phenotypes

immune system phenotype

enlarged spleen

increased spleen weight

spleen hyperplasia

abnormal leukocyte cell number

increased plasmacytoid dendritic cell number

decreased B-1 B cell number

increased marginal zone B cell number

increased plasma cell number

decreased NK T cell number

increased macrophage cell number

increased monocyte cell number

increased leukocyte cell number

abnormal alpha-beta T cell morphology

abnormal peritoneal macrophage morphology

abnormal spleen morphology

increased spleen germinal center number

abnormal immunoglobulin level

increased IgA level

increased IgE level

increased IgG2b level

increased IgG3 level

increased IgG level

increased IgM level

increased circulating CXCL10 level

increased circulating interferon-gamma level

enlarged lymph nodes

lymph node hyperplasia

increased anti-nuclear antigen antibody level

Availability

Mouse Genotype

Pld4^em1(IMPC)Mbp/Pld4^em1(IMPC)Mbp

Pld4^thss/Pld4^thss

Pld4^tm1.2Nemz/Pld4^tm1.2Nemz

*

Pld4^tm1.1Nemz/Pld4^tm1.1Nemz
Tg(Itgax-cre)1-1Reiz/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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